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fluoxetine necklace | silver gold_plated or the comparative neuroanatomy offluoxetine necklace sterling silver Fluoxetine changed how depression is treated. Not because it worked better than older drugs, but because it was safe enough for a family physician to prescribe alone. Approved by the FDA in 1987 as Prozac, it moved psychiatric care from specialist consultation into primary care. The Science Behind Fluoxetine Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that blocks the serotonin transporter (SERT),