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4616-C ODEVIXIBAT EFFICACY AND SAFETY ACROSS PATIENT SUBGROUPS: AN EVALUATION OF POOLED DATA FROM THE PEDFIC 1 AND PEDFIC 2 TRIALS Ekkehard Sturm 1 , Reha Artan 2 , Ulrich Baumann 3 , Piotr Czubkowski 4 , Girish Gupte 5 , Özlem Durmaz 6 , Emmanuel M

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Braak’s hypothesis suggests that the α-synuclein pathology begins in the ENS and then migrates to the brain, passing through the brainstem, midbrain, basal forebrain, and finally the cortical areas [118, 119]